May 22, 2012
Topics A-Z Drugs Liver-related adverse effects associated with terbinafine and orlistat
Liver-related adverse effects associated with terbinafine and orlistat |
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Dear Ask The Doctor: Doctor: I was taking Terbinafine for 3 months and just stopped last month. I did not know that I was supposed to limit alcohol during that time and now I'm not sure if the Terbinafine was effective OR if the combination caused liver damage. Now, to boot, I just started Alli to lose weight & I'm hearing that this too causes liver damage! I have dropped the alcohol due to dieting. Should I stop the Alli? Get a liver test? Carol Dear Carol: Liver enzyme abnormalities have been reported in up to 3% of patients taking oral terbinafine. In addition rare cases of liver failure (including fatal cases) have been reported following oral treatment. The U.S. Food and Drug Administration (FDA) is currently analyzing the use of Orlistat (Alli) and reports of liver-related adverse events. Between 1999 and October 2008, 32 reports of serious liver injury (commonly reported as jaundice, weakness, and abdominal pain), including six cases of liver failure, were submitted to the FDA’s Adverse Event Reporting System. Therefore I would advise attending your family doctor for a current baseline liver function test to determine if liver function is improving or deteriorating with your current regimen. It is also vital to report any signs/symptoms associated with liver injury (eg, fatigue, fever, jaundice, brown urine, nausea, vomiting, abdominal pain) to your family doctor immediately.. |
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| Last Updated ( Wednesday, 06 October 2010 ) |
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