What are other considerations in demyelinating conditions?

Dear Ask The Doctor: I am 52 years old, I have been sick since 2005. I have had MRI several times in the cranial area and they found an area of interest that appears to be cloudy white with graying areas. I am always tired, I have had I called them out of body experiences, my wife says I sort of blackout while awake. I am always cold, I get severe headaches,I recently suffered the loss of eeling in two fingers in my right hand - they still move just no sensation. I also have demylinization of the nerves in my brain. They checked for MS, ALS, Lyme, Lupus, and all have been proven NOT. They also have done a genetics test for CADASIL which also came back negative. My question is Can there be another diease causing this.

I am just as puzzled as your doctors. Your symptoms are consistent with a demyelinating disease since there is only a loss of sensation. Yours could be a rare kind. As far as I know, the tests you underwent detected the more common causes of your symptoms. Other conditions worth considering are autoimmune disorders (antiphospholipid andtibidy syndrome, SLE), HIV, tumors (lymphoma, brain tumors), Sarcoid, Syphilis, to name a few. Your doctors may have done tests already to have ruled out these conditions but it is still worth asking. I do hope this helps and take care always.