May 26, 2012
Topics A-Z Infections What are the long term complications of MBL Pathway deficiency in a 2 year old?
What are the long term complications of MBL Pathway deficiency in a 2 year old? |
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Dear Ask The Doctor: What are the long term complications of MBL Pathway deficiency in a 2 year old? Dear Alexis: I understand your concern about MBL pathway. The Mannose binding Lectin is a blood serum protein that plays a role in the innate immune response by binding on the surface of a wide range of pathogens (viruses, bacteria, fungi, protozoa ) where it can activate the complement system or act directly as an enhancer of a part of the immune system in charge of getting rid of pathogens. Certainly a deficiency of this pathway particularly common in infants has been related to recurrent respiratory tract infection, otitis media, and chronic diarrhea in a short a long term. Other non-infectious diseases which might be considered to be developed after several years include systemic lupus erythematosus, rheumatoid arthritis, cystic fibrosis and common variable immunodeficiency. I hope I cleared your doubt. |
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| Last Updated ( Tuesday, 18 January 2011 ) |
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