About Genetic problems in generation

Patient : My name is Bhaskar from hyderabad,india.. My marriage settled with my own sister's daughter. My age is 28 and her age is 18. my blood groups is o+ve and her blood group A+ve.. This is the first blood relation marriage in my family and in her family.. so what type complications to be face in future.. Is there any possibility of generation problem will come.. please suggest me to proceed for marriage or not.
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