Thanks for using "Ask The Doctor" for posting your query.
Zoloft works for more than 24 hours. If you having drowsiness while working the third shift then it would be wise to get the medicine switched. Among the other options available Bupropion is a good option. Its a good antidepressant and doesn't cause sedation and will not interfere in the work.
Do meet your doctor and consider this option.
Hope this helps,
Wish you a good health.
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