Patient :I have Parkinson's and the mutation MAOB rs1799836 +/+. Does this mutation accelerates the degradation of dopamine, making my PD symptoms worse, or slows it down (downregulates it), relieving my symptoms?
Hi, Welcome to ATD. Thanks for your query.
MAOB degrades dopamine and has an important role in PD pharmacological treatment. This enzyme is encoded by the MOAB gene mapped at chromosome Xp11. Studies did not observe a significant association between levodopa doses used for 5 years and the polymorphism (rs1799836) in MAOB. There have been conflicting results in studies evaluating the effect of MAOB polymorphism. Some studies have shown increased risk for PD with this polymorphism while others din't.
At the moment we do not know the effect of MAO mutations on people with Parkinson's. Irrespective of the mutation status we are able to treat patients in the same fashion. So the most important part is to simply optimize the meds to treat your symptoms.
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