My Friend accidently took 450mcg of eltroxin tabs,she is a

Patient : My Friend accidently took 450mcg of eltroxin tabs,she is a hypothyroid patient and taking electroxin for some 18 years,she started taking eltroxin 50mcg in the age of 13,now for the past one year she is taking 75mcg.Yesterday accidently she took some 450mcg,till now she is normal.her age is 29,she was got married just before 5 months,what will be the effects of this intake of 450mcg?
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