Welcome to ATD. Thank you for the query.
Unilateral leg edema is generally due to a local cause such as allergic reaction, deep vein thrombosis, venous insufficiency, or lymphedema.
Most patients over age 50 with leg edema have venous insufficiency, but if the etiology is unclear, a short list of laboratory tests will help rule out systemic disease: complete blood count, urinalysis, electrolytes, creatinine, blood sugar, thyroid-stimulating hormone, and albumin. A serum albumin below 2 g/dL often leads to edema and can be caused by liver disease, nephrotic syndrome, or protein-losing enteropathy.Additional tests are indicated depending on the clinical presentation.
Hope this helps. Take care.
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