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Usually such generalized fatigue, stress, weight loss are due to anemia, malabsorption syndrome, Calcium and Vitamin D deficiency.
She requires immediate care by evaluation as most concerning is the weight loss she is having.
I would advise you to get following tests done:
1. Fasting Blood Sugar- to rule out diabetes
2. Thyroid Profile- to rule out hypothyroidism
3. Hemogram- to check for anemia.
4. Serum Calcium and Vitamin D levels- to see for the deficiencies.
If any issues are found in her reports she would be treated accordingly.
I hope it helps.
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