New Diminished Thirst?

Patient : I have been feeling generally ill for 6 months with decreased appetite (almost nonexistent) with fatigue, sleepiness, insomnia, constipation. Recently I now have almost no thirst sensation and only urinated once yesterday. Any ideas as to why this might be happening or what I should have checked? Blood work taken within the past few months doesn't show anything out of the ordinary, including thyroid test. Thanks
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