The statins are the most widely used drugs to target LDL Cholesterol, with reductions of 18% to 55%, depending on which statin is used. Studies have shown that atorvastatin is slightly superior in action, in comparison to the other statins, without increasing the side-effect profile. There are several alternatives available to target LDL with different modes of action. Ezetemibe(Zetia) inhibits the absorption of cholesterol from the intestine; and Bile acid sequestrants such as Cholestyramine, prevent the reabsorption of cholesterol-containing bile acids from the intestine. Nicotinic acid raises HDL cholesterol, with a small reducing effect on LDL cholesterol. This may be difficult to tolerate due to unwanted side-effects. However all these drugs are less effective than statins, in lowering LDL cholesterol, and are often used in addition to a statin for dual-therapy.
These Q&A’s are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.