Redness around the penis hole

Patient : Last week, after sex, I noticed that the hole around my penis was red as well as having a few red spots on the head. I applied some cream the doctor gave me for a rash I have and the red spots mostly went away, but the redness around the hole did not. My wife thinks I may have an STD, but I haven't had sex with anyone but her in 4 years and she swears the same. Please help!
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