Risk of an affected child (SS genotype) in Sickle cell Disease

Patient

Q: Hello my genotype is AS and my fiancee also is AS, we are worried about the posibility of having children without SS genotype? what do we do

Doctor

A:   I assume you are referring to the inheritance of sickle cell disease, an autosomal recessive condition. If both you are your fiancé are AS genotype then you are both carriers of the abnormal gene. During each pregnancy you will have a 1 in 4 (25%) chance of having an affected child SS genotype, a 1 in 4 (25%) chance of a normal child AA genotype, and a 1 in 2 chance (50%) of a carrier child AS genotype.

Related Q&A

Q: What to take if you dont want to be pregnant and your period hasn't come for a month

Q: I rubbed my penis over my girlfriend's vagina. I did not ejaculate. It was covered in pre-ejaculate though and I had ...

Q: Hi I'm a 17 year old female and two weeks ago I started taking the contraceptive pill. Unfortunately I wasn't infor...

Q: If I my girlfriend and I were grinding naked during ovulation or the day before and I had Precum on my finger and fin...

Q: Had sex on day 14/15 of my cycle which is usually 27/28 days. We used a condom but it broke . He wasn't near ejacula...

 
DOCTOR ADVISORY BOARD
218

Dr. James Obaji M.D.

  • 247 Reviews
  • Family Physician
173

Dr. Suneel Sharman M.D.

  • 190 Reviews
  • Family Physician
138

Dr. Pat Golden M.D.

  • 169 Reviews
  • Cardiologist
98

Dr. Kunaal Jindal M.D.

  • 112 Reviews
  • Plastic Surgeon
CNN
BBC
MSNBC
CBS
abcNews
FoxNews