Risk of an affected child (SS genotype) in Sickle cell Disease

Patient : Hello my genotype is AS and my fiancee also is AS, we are worried about the posibility of having children without SS genotype? what do we do
Doctor :   I assume you are referring to the inheritance of sickle cell disease, an autosomal recessive condition. If both you are your fiancé are AS genotype then you are both carriers of the abnormal gene. During each pregnancy you will have a 1 in 4 (25%) chance of having an affected child SS genotype, a 1 in 4 (25%) chance of a normal child AA genotype, and a 1 in 2 chance (50%) of a carrier child AS genotype.

Related Q&A

Q: Hi, am having a crypic pregnancy. I am about 31 fetal weeks, 33 gestational weeks. I am now having.daily Braxton hick...

Q: Can I take Tylenol when pregnant? I am a 32 year old women who is 28 weeks pregnant. I've had some massive splitting ...

Q: Insulin does not cross the placenta but glucose does, how will the baby’s body handle elevated glucose in the m...

Q: Is it possible to get pregnant while on the implanon? And if so, would the fetus survive or would it die with the imp...

Q: I have been on BCP for a while..It it normal to still breakthrough bleed? The blood is dark red to brown what can I d...


Dr. James Obaji M.D.

  • 247 Reviews
  • Family Physician

Dr. Suneel Sharman M.D.

  • 190 Reviews
  • Family Physician

Dr. Pat Golden M.D.

  • 169 Reviews
  • Cardiologist

Dr. Kunaal Jindal M.D.

  • 112 Reviews
  • Plastic Surgeon