Sore breasts and nipples

Patient : I was on the depo shot and my last shot was in march and still havent had a period but I had spotting about a week ago for about three or four days after that my cervix became tender to feel and for sex for about a week maybe less and my breasts started hurting a few days later they only hurt at the top from nipple up and are more painful after waking up in the mornings and now two days later my nipples are very tender even my bra (that fits like it should) makes them hurt I'm not sure what this is what do you think? i have taken a pregnancy test that was negative and since i havent had a cycle im not sure when to test.. my breasts have never hurt before my period or anything either...
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