Tretinoin – what could have happened?

Patient: Hello, I have a question regarding the use of “Retin-A Gel 0.025%” (Tretinoin) acne cream.My wife is pregnant. First day of her last period was July 21. Conception could have only occurred between July 26 – 31 inclusive.My wife applied Retin-A Gel on the evenings (before sleep) of July 21, 22, 23, 24, 25 and on August 19. She has not and will not use Retin-A Gel again during this pregnancy.Could any adverse effect have been caused to our unborn baby? Thank you.

Doctor: