Worsening impaired circulation in legs when sitting

Patient : I am a 35 year old woman, normal weight, moderately active. I am experiencing persistent and worsening pain in my legs due to the circulation being impaired. This occurs only when sitting which is problematic because I am a writer and spend the bulk of my day at my desk. I have tried every position possible, adding pillows beneath me, sitting on the floor on a cushion with my legs propped up...nothing helps. After a few minutes in any position, I start to feel pain in the back of my quadruceps and will sometimes get pins and needles in my legs and feet if I wait too long to switch positions. Even in my early twenties I was never able to sit 'indian style' for long because I would lose circulation. So the problem is long-standing, but is getting worse with age. The discomfort is also interfering with my ability to focus on my work due to the constant discomfort and need to keep switching positions. I am concerned about developing blood clots as my father has had DVT and my grandmother had multiple strokes. What may cause these circulation problems and is there anything I can do to prevent it?
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